It would affect fuel trim but whether the effect is noticeable would depend on the degree of the leak.
In your case however, if the line feeding the booster is the source of the noise, you may be able to track it down using the Mk1 Lughole.
Failing that, if you disconnect the line at source and plug the hole, you will be able to rule it out/in conclusively.
The vacuum line is quit expensive to replace BTW.